Sr./Scientist, Bioanalysis and Biomarker Development
Role:
This laboratory-based position is responsible for the development, qualification, and execution of bioanalytical and biomarker assays (e.g., ligand binding assay, enzyme activity assay, ELISPOT, flow cytometry, various PCR) to support platform understanding and nonclinical research and development across pipeline programs within the Be Bio R&D organization. The successful candidate will utilize their knowledge of bioanalysis and biomarker development to evaluate quality attributes of B Cell Medicine (BCM), BCM engraftment and biodistribution, and pharmacology/efficacy biomarkers in vitro, ex vivo and in preclinical model systems. This position requires hands-on experience and knowledge of developing and qualifying bioanalytical and biomarker assays to support both preclinical research, nonclinical development, and platform research teams. This individual will also act as a technical subject matter expert for various assays routinely used at Be Bio and contribute to expanding the repertoire of bioanalytical and biomarker assays. This position requires prior experience in generating and maintaining fit-for-purpose test methods, assay worksheets, SOPs, data documentation, management and visualization, and supporting transfer of assays to CRO’s. This position has tremendous opportunities to contribute to precision-engineered B cell platform advancement, preclinical research and development of BCMs towards clinic and ultimately improving patient lives.
Responsibilities:
- Develop, optimize, and qualify molecular, biochemical, and cellular assays to support precision-engineered B cell platform advancement, preclinical research and development of BCM (e.g., ligand binding assay, enzyme activity assay, ELISPOT, flow cytometry, PCR)
- Perform sample analysis with cells, cell supernatant, blood samples, and animal tissues on the timely basis aligning with the project milestone
- Ensure assays are robust and reproducible and transferable to external labs by performing necessary qualification tests and thorough documentation
- Document procedures and results to regulatory standards and ensure data integrity
- Evaluate and manage critical reagents
- Summarize and communicate results and data trends with cross functional teams
- Cross train and mentor junior scientists
- Keep up to date on the industry best practice and regulatory requirements on bioanalytical and biomarker assays in support of cell and gene therapy product development
Experience, Education, Specialized Knowledge, and Skills:
Must thrive in a fast-paced, growing, and innovative environment with changing priorities where flexibility, resourcefulness, resiliency, and communication skills are key. Excellent interpersonal skills, ability to develop important relationships and open communication with your stakeholders and being an all-around good company citizen are essential.
- PhD in life sciences with 5+ years of bioanalysis experience or BS / Master's degree with 10+ years of relevant experience. Title will be based on experience.
- Expertise and hands-on experience with ligand binding assays (MSD preferred) and enzyme activity assays is a must.
- Experienced with bioanalytical and biomarker assay development, qualification, and sample analysis, documentation, and assay trouble-shooting, is highly desirable
- Knowledge and hands-on experience with nucleic acid quantification (RT-qPCR, ddPCR), flow cytometry and cell based assays
- Excellent communication, technical writing, and presentation skills
- Self-motivated, detailed oriented, and a good problem-solving ability
- Must enjoy working in a fast-paced, dynamic, and highly collaborative environment
About Be Biopharma
Be Biopharma (“Be Bio”) is pioneering Engineered B Cell Medicines (BCM) to dramatically improve patients’ lives who are living with cancer, rare diseases and other serious conditions. With eyes locked on the patient, our team of purpose-driven scientists, technologists, manufacturing experts and business builders collaborate to create a bold new class of cell therapies. Be Bio was founded in October 2020 by Longwood Fund and B cell engineering pioneers David Rawlings, M.D., and Richard James, Ph.D. from Seattle Children’s Research Institute. Be Bio is backed by ARCH Venture Partners, Atlas Venture, RA Capital Management, Alta Partners, Longwood Fund, Bristol Myers Squibb and Takeda Ventures. Since our founding, Be Bio’s investors have committed over $180 million to enable the Company to re-imagine medicine based on the power of B cell therapy. For more information, please visit us at Be.Bio and our LinkedIn page.
Culture
The beating heart of Be Bio is our People and together we are building a culture driven by purpose, passion, and that’s full of character. We are “all-in” as we align ourselves with patients who need our medicines, and we embrace the highest standards of transparency, excellence, candor, collaboration, and team-based science with a shared ownership of company milestones and successes.
Our commitment to our team members is to deliver a compelling, dynamic work experience that enables them to continually stretch, grow, and learn, that enriches their lives, that fosters a sense of belonging and community, and that goes above and beyond to support them in big, meaningful ways in both their personal and professional lives. Be Bio is a team that works hard, plays hard, and supports each other on our shared journey to get transformative medicines to patients who need them.
